Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT

• Main Authors: Md. Ajat, Mohd Mokrish, Molenaar, Martijn, Brouwers, Jos F. H. M., Vaandrager, Arie B., Houweling, Martin, Helms, J. Bernd
• Format: Article
• Language: English
• Published: Elsevier 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/62023/1/Hepatic%20stellate%20cells%20retain%20.pdf; http://psasir.upm.edu.my/id/eprint/62023/; https://www.sciencedirect.com/science/article/pii/S1388198116303006?via%3Dihub#!
• Institution: Universiti Putra Malaysia

Hepatic stellate cells (HSCs) play an important role in liver physiology and under healthy conditions they have a quiescent and lipid-storing phenotype. Upon liver injury, HSCs are activated and rapidly lose their retinyl ester-containing lipid droplets. To investigate the role of lecithin:retinol a...