IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation

• Main Authors: Mitchell, Ruth E., Hassan, Masriana, Burton, Bronwen R., Britton, Graham, Hill, Elaine V., Verhagen, Johan, Wraith, David C.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/62080/1/IL-4%20enhances%20IL-10%20production%20in.pdf; http://psasir.upm.edu.my/id/eprint/62080/; https://www.nature.com/articles/s41598-017-11803-y
• Institution: Universiti Putra Malaysia

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4+ T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 pr...