Light chain multiple myeloma: an evaluation of its biochemical investigations
Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Society of Pathologists
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62306/1/Light%20chain%20multiple%20myeloma.pdf http://psasir.upm.edu.my/id/eprint/62306/ http://www.mjpath.org.my/2017/v39n3/index.php |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM) makes up almost 20% of myelomas. Clinical manifestation is often heralded by hypercalcaemia, renal impairment, normocytic normochromic anaemia and bone lesions, reflecting end-organ damage, collectively known as the acronym CRAB. In particular, free light chain nephrotoxicity accounts for the high prevalence of renal impairment seen in LCMM. This case illustrates a typical presentation of LCMM with focal discussion on its initial and diagnostic, as well as prognostic biochemical investigations. |
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