S1PR1 drives a feedforward signaling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

• Main Authors: Vrzalikova, K., Ibrahim, M., Vockerodt, M., Perry, T., Margielewska, S., Lupino, L., Nagy, E., Soilleux, E., Liebelt, D., Hollows, R., Last, A., Reynolds, G., Abdullah, M., Curley, H., Care, M., Krappmann, D., Tooze, R., Allegood, J., Spiegel, S., Wei, W., Woodman, C. B. J., Murray, P. G.
• Format: Article
• Language: English
• Published: Springer Nature Limited 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/63162/1/S1PR1%20drives%20a%20feedforward%20signalling%20loop%20to%20regulate%20BATF3%20and%20the%20transcriptional%20.pdf; http://psasir.upm.edu.my/id/eprint/63162/; https://www.nature.com/articles/leu2017275.pdf
• Institution: Universiti Putra Malaysia

The Hodgkin/Reed–Sternberg cells of classical Hodgkin lymphoma (HL) are characterised by the aberrant activation of multiple signalling pathways. Here we show that a subset of HL displays altered expression of sphingosine-1-phosphate (S1P) receptors (S1PR)s. S1P activates phosphatidylinositide 3-kin...