Stem cell therapies for reversing vision loss

Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage...

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Main Authors: Higuchi, Akon, Kumar, S. Suresh, Benelli, Giovanni, Alarfaj, Abdullah A., Munusamy, Murugan A., Umezawa, Akihiko, Murugan, Kadarkarai
Format: Article
Language:English
Published: Cell Press 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf
http://psasir.upm.edu.my/id/eprint/63289/
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Institution: Universiti Putra Malaysia
Language: English
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spelling my.upm.eprints.632892018-09-26T01:50:19Z http://psasir.upm.edu.my/id/eprint/63289/ Stem cell therapies for reversing vision loss Higuchi, Akon Kumar, S. Suresh Benelli, Giovanni Alarfaj, Abdullah A. Munusamy, Murugan A. Umezawa, Akihiko Murugan, Kadarkarai Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage in combination with stem cell therapy for macular degeneration disease treatment. Retinal pigment epithelium (RPE) differentiated from hPSCs is typically used in most clinical trials for treating patients, whereas bone marrow mononuclear cells (BMNCs) or mesenchymal stem cells (MSCs) are intravitreally transplanted, undifferentiated, into patient eyes. We also discuss reported negative effects of stem cell therapy, such as patients becoming blind following transplantation of adipose-derived stem cells, which are increasingly used by 'stem-cell clinics'. Cell Press 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf Higuchi, Akon and Kumar, S. Suresh and Benelli, Giovanni and Alarfaj, Abdullah A. and Munusamy, Murugan A. and Umezawa, Akihiko and Murugan, Kadarkarai (2017) Stem cell therapies for reversing vision loss. Trends in Biotechnology, 35 (11). 1102 - 1117. ISSN 0167-7799; ESSN: 1879-3096
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage in combination with stem cell therapy for macular degeneration disease treatment. Retinal pigment epithelium (RPE) differentiated from hPSCs is typically used in most clinical trials for treating patients, whereas bone marrow mononuclear cells (BMNCs) or mesenchymal stem cells (MSCs) are intravitreally transplanted, undifferentiated, into patient eyes. We also discuss reported negative effects of stem cell therapy, such as patients becoming blind following transplantation of adipose-derived stem cells, which are increasingly used by 'stem-cell clinics'.
format Article
author Higuchi, Akon
Kumar, S. Suresh
Benelli, Giovanni
Alarfaj, Abdullah A.
Munusamy, Murugan A.
Umezawa, Akihiko
Murugan, Kadarkarai
spellingShingle Higuchi, Akon
Kumar, S. Suresh
Benelli, Giovanni
Alarfaj, Abdullah A.
Munusamy, Murugan A.
Umezawa, Akihiko
Murugan, Kadarkarai
Stem cell therapies for reversing vision loss
author_facet Higuchi, Akon
Kumar, S. Suresh
Benelli, Giovanni
Alarfaj, Abdullah A.
Munusamy, Murugan A.
Umezawa, Akihiko
Murugan, Kadarkarai
author_sort Higuchi, Akon
title Stem cell therapies for reversing vision loss
title_short Stem cell therapies for reversing vision loss
title_full Stem cell therapies for reversing vision loss
title_fullStr Stem cell therapies for reversing vision loss
title_full_unstemmed Stem cell therapies for reversing vision loss
title_sort stem cell therapies for reversing vision loss
publisher Cell Press
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf
http://psasir.upm.edu.my/id/eprint/63289/
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