The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications

• Main Authors: Govindaraj, Dharman, Rajan, Mariappan, Munusamy, Murugan A., Alarfaj, Abdullah A., Sadasivuni, Kishor Kumar, Kumar, S. Suresh
• Format: Article
• Language: English
• Published: Elsevier 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf; http://psasir.upm.edu.my/id/eprint/63534/; https://www.sciencedirect.com/science/article/pii/S1549963417301478?via%3Dihub
• Institution: Universiti Putra Malaysia

Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats.