Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V

Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V

Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results...

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Main Authors: Kusumaningtyas, Eni, Tan, Wen Siang, Zamrod, Zulkeflie, Eshaghi, Majid, Yusoff, Khatijah
Format: Article
Language:English
English
Published: Springer Wien 2004
Online Access:http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf
http://psasir.upm.edu.my/id/eprint/693/
http://dx.doi.org/10.1007/s00705-004-0336-5
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Institution: Universiti Putra Malaysia
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spelling my.upm.eprints.6932013-05-27T06:50:12Z http://psasir.upm.edu.my/id/eprint/693/ Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V Kusumaningtyas, Eni Tan, Wen Siang Zamrod, Zulkeflie Eshaghi, Majid Yusoff, Khatijah Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses. Springer Wien 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf Kusumaningtyas, Eni and Tan, Wen Siang and Zamrod, Zulkeflie and Eshaghi, Majid and Yusoff, Khatijah (2004) Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V. Archives of Virology, 149 (1). pp. 1859-1865. ISSN 0304-8608 http://dx.doi.org/10.1007/s00705-004-0336-5 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses.
format Article
author Kusumaningtyas, Eni
Tan, Wen Siang
Zamrod, Zulkeflie
Eshaghi, Majid
Yusoff, Khatijah
spellingShingle Kusumaningtyas, Eni
Tan, Wen Siang
Zamrod, Zulkeflie
Eshaghi, Majid
Yusoff, Khatijah
Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
author_facet Kusumaningtyas, Eni
Tan, Wen Siang
Zamrod, Zulkeflie
Eshaghi, Majid
Yusoff, Khatijah
author_sort Kusumaningtyas, Eni
title Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
title_short Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
title_full Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
title_fullStr Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
title_full_unstemmed Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
title_sort existence of two form of l protein of newcastle disease virus isolates due to a compensatory mutation in domain v
publisher Springer Wien
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf
http://psasir.upm.edu.my/id/eprint/693/
http://dx.doi.org/10.1007/s00705-004-0336-5
_version_ 1643821892472143872

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