Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

• Main Authors: Razali, Nurul Atika, Nazarudin, Nur Amiza, Lai, Kok Song, Abas, Faridah, Ahmad, Syahida
• Format: Article
• Language: English
• Published: BioMed Central 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/72155/1/Curcumin%20derivative.pdf; http://psasir.upm.edu.my/id/eprint/72155/; https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-018-2223-8
• Institution: Universiti Putra Malaysia

Background: Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited in efficacy and associated with several common side effects. Therefore, alterna...