Small cell neuroendocrine carcinoma: a rare second primary malignancy after treatment of nasopharyngeal carcinoma

Small cell neuroendocrine carcinoma (SCNEC) of the nasopharynx and nasal cavity is a rare condition. It is an aggressive malignancy with a high recurrence rate. Despite its rarity in the sinonasal region, it may occur as a second primary malignancy. Patients with cancer of the head and neck region a...

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Bibliographic Details
Main Authors: Madhusudhan, Krishnamoorthy, Hassan, Nor Eyzawiah, Md Shukri, Norasnieda, Hitam, Shahrul, Bakrin, Ikmal Hisyam
Format: Article
Language:English
Published: Sciendo 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73906/1/Small%20cell%20neuroendocrine%20carcinoma%20a%20rare%20second%20primary%20malignancy%20after%20treatment%20of%20nasopharyngeal%20carcinoma.pdf
http://psasir.upm.edu.my/id/eprint/73906/
https://content.sciendo.com/view/journals/rjr/8/31/article-p187.xml?tab_body=abstract
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Institution: Universiti Putra Malaysia
Language: English
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Summary:Small cell neuroendocrine carcinoma (SCNEC) of the nasopharynx and nasal cavity is a rare condition. It is an aggressive malignancy with a high recurrence rate. Despite its rarity in the sinonasal region, it may occur as a second primary malignancy. Patients with cancer of the head and neck region are more prone to develop a second primary tumor due to the field cancerization phenomenon, and a higher incidence is seen in those who have previously received radiation therapy. A detailed clinical and histopathological examination is pivotal to diagnose SCNEC as a second primary malignancy. We wish to highlight such a peculiar case from our center.