Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone

• Main Authors: Othman, Nurhanisah, Masarudin, Mas Jaffri, Cha, Yee Kuen, Dasuan, Nurul Azira, Abdullah, Luqman Chuah, Md. Jamil, Siti Nurul Ain
• Format: Article
• Language: English
• Published: MDPI 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/74055/1/Synthesis%20and%20optimization%20of%20chitosan%20nanoparticles%20loaded%20with%20l-ascorbic%20acid%20and%20thymoquinone.pdf; http://psasir.upm.edu.my/id/eprint/74055/
• Institution: Universiti Putra Malaysia

The combination of compounds with different classes (hydrophobic and hydrophilic characters) in single chitosan carrier is a challenge due to the hydrophilicity of chitosan. Utilization of l-ascorbic acid (LAA) and thymoquinone (TQ) compounds as effective antioxidants is marred by poor bioavailabili...