Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology

Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized us...

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Main Authors: Chong, Wai Ting, Tan, Chin Ping, Cheah, Yoke Kqueen, Lajis, Ahmad Firdaus, Mat Dian, Noor Lida Habi, Kanagaratnam, Sivaruby, Lai, Oi Ming
Format: Article
Language:English
Published: Public Library of Science 2018
Online Access:http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf
http://psasir.upm.edu.my/id/eprint/75164/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202771
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spelling my.upm.eprints.751642019-11-27T03:42:12Z http://psasir.upm.edu.my/id/eprint/75164/ Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology Chong, Wai Ting Tan, Chin Ping Cheah, Yoke Kqueen Lajis, Ahmad Firdaus Mat Dian, Noor Lida Habi Kanagaratnam, Sivaruby Lai, Oi Ming Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5–15 wt%), co-solvent (10–30 wt%) and homogenization pressure (500–700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations. Public Library of Science 2018-08-24 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf Chong, Wai Ting and Tan, Chin Ping and Cheah, Yoke Kqueen and Lajis, Ahmad Firdaus and Mat Dian, Noor Lida Habi and Kanagaratnam, Sivaruby and Lai, Oi Ming (2018) Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology. PLoS One, 13 (8). pp. 1-22. ISSN 1932-6203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202771 10.1371/journal.pone.0202771
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Red palm oil (RPO) is a natural source of Vitamin E (70–80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5–15 wt%), co-solvent (10–30 wt%) and homogenization pressure (500–700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations.
format Article
author Chong, Wai Ting
Tan, Chin Ping
Cheah, Yoke Kqueen
Lajis, Ahmad Firdaus
Mat Dian, Noor Lida Habi
Kanagaratnam, Sivaruby
Lai, Oi Ming
spellingShingle Chong, Wai Ting
Tan, Chin Ping
Cheah, Yoke Kqueen
Lajis, Ahmad Firdaus
Mat Dian, Noor Lida Habi
Kanagaratnam, Sivaruby
Lai, Oi Ming
Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
author_facet Chong, Wai Ting
Tan, Chin Ping
Cheah, Yoke Kqueen
Lajis, Ahmad Firdaus
Mat Dian, Noor Lida Habi
Kanagaratnam, Sivaruby
Lai, Oi Ming
author_sort Chong, Wai Ting
title Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
title_short Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
title_full Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
title_fullStr Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
title_full_unstemmed Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
title_sort optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by tween80-span 80 using response surface methodology
publisher Public Library of Science
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/75164/1/Optimization%20of%20process%20parameters%20in%20preparation%20of%20tocotrienol.pdf
http://psasir.upm.edu.my/id/eprint/75164/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202771
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