Evaluation of a recombinant Newcastle disease virus expressing human IL12 against human breast cancer

• Main Authors: Mohamed Amin, Zahiah, Che Ani, Muhamad Alhapis, Tan, Sheau Wei, Yeap, Swee Keong, Mohammed Alitheen, Noorjahan Banu, Syed Najmuddin, Syed Umar Faruq, Kalyanasundram, Jeevanathan, Chan, Soon Choy, Veerakumarasivam, Abhimanyu, Chia, Suet Lin, Yusoff, Khatijah
• Format: Article
• Published: Nature Publishing Group 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/79739/; https://www.nature.com/articles/s41598-019-50222-z
• Institution: Universiti Putra Malaysia

The Newcastle disease virus (NDV) strain AF2240 is an avian avulavirus that has been demonstrated to possess oncolytic activity against cancer cells. However, to illicit a greater anti-cancer immune response, it is believed that the incorporation of immunostimulatory genes such as IL12 into a recomb...