Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome

• Main Authors: Md Yusof, Hadri Hadi, Lee, Han Chung, Mohamed Seth, Eryse Amira, Wu, Xiangzhong, Hewitt, Chelsee A., Scott, Hamish S., Cheah, Pike See, Li, Yue Ming, Chau, De Ming, Ling, King Hwa
• Format: Article
• Published: Springer 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/79827/; https://link.springer.com/article/10.1007/s12031-019-01275-2
• Institution: Universiti Putra Malaysia

Notch signalling pathway is involved in the proliferation of neural progenitor cells (NPCs), to inhibit neuronal cell commitment and to promote glial cell fate. Notch protein is cleaved by gamma-secretase, a multisubunit transmembrane protein complex that releases the Notch intracellular domain (NIC...