Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression

Unhealthy eating habits and lack of physical activities are among the contributing factors for obesity and diabetes. It has been reported that consumption of naturally occurring phenolics could exert beneficial effects toward these diseases. Therefore, this study aims to evaluate the ability of phen...

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Main Authors: Tan, Seok Tyug, Ismail, Amin, Hamid, Muhajir, Chong, Pei Pei, Sun, Jian
Format: Article
Language:English
Published: Wiley-Blackwell Publishing 2019
Online Access:http://psasir.upm.edu.my/id/eprint/82217/1/Soy%20husk%20.pdf
http://psasir.upm.edu.my/id/eprint/82217/
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12843
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Institution: Universiti Putra Malaysia
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spelling my.upm.eprints.822172020-12-16T06:16:23Z http://psasir.upm.edu.my/id/eprint/82217/ Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression Tan, Seok Tyug Ismail, Amin Hamid, Muhajir Chong, Pei Pei Sun, Jian Unhealthy eating habits and lack of physical activities are among the contributing factors for obesity and diabetes. It has been reported that consumption of naturally occurring phenolics could exert beneficial effects toward these diseases. Therefore, this study aims to evaluate the ability of phenolic-rich soy husk powder extract (SHPE) in modifying the physical and biochemical parameters for obesity and diabetes. Forty-nine Sprague Dawley rats were divided into seven groups, including three supplementary/treatment groups. Rats in supplementary/treatment groups were provided with either 4 mg/kg BW Rosiglitazone Maleate, 250 mg SHPE/kg BW, or 500 mg SHPE/kg BW. The effectiveness of SHPE in alleviating obesity-diabetes was evaluated by measuring body weight (physical parameter), blood glucose metabolisms (biochemical parameters), and PPARγ expression. Findings in the present study revealed that short-term SHPE and Rosiglitazone Maleate administration improved the physical and biochemical parameters of obese-diabetic rats. In addition, SHPE was also demonstrated to upregulate PPARγ expression in adipocytes. These findings suggest that soy husk could emerge as a potential hypoglycemic and anti-adipogenic nutraceutical in future. PRACTICAL APPLICATIONS: This was the first study to evaluate the potential effects of soy husk against the parameters of obese-diabetes in rats. In addition, promising effects derived from this study might explore the possibility of soy husk to be utilized as an antidiabetes nutraceutical. Wiley-Blackwell Publishing 2019-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82217/1/Soy%20husk%20.pdf Tan, Seok Tyug and Ismail, Amin and Hamid, Muhajir and Chong, Pei Pei and Sun, Jian (2019) Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression. Journal of Food Biochemistry, 43 (5). art. no. e12843. ISSN 0145-8884; ESSN: 1745-4514 https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12843 10.1111/jfbc.12843
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Unhealthy eating habits and lack of physical activities are among the contributing factors for obesity and diabetes. It has been reported that consumption of naturally occurring phenolics could exert beneficial effects toward these diseases. Therefore, this study aims to evaluate the ability of phenolic-rich soy husk powder extract (SHPE) in modifying the physical and biochemical parameters for obesity and diabetes. Forty-nine Sprague Dawley rats were divided into seven groups, including three supplementary/treatment groups. Rats in supplementary/treatment groups were provided with either 4 mg/kg BW Rosiglitazone Maleate, 250 mg SHPE/kg BW, or 500 mg SHPE/kg BW. The effectiveness of SHPE in alleviating obesity-diabetes was evaluated by measuring body weight (physical parameter), blood glucose metabolisms (biochemical parameters), and PPARγ expression. Findings in the present study revealed that short-term SHPE and Rosiglitazone Maleate administration improved the physical and biochemical parameters of obese-diabetic rats. In addition, SHPE was also demonstrated to upregulate PPARγ expression in adipocytes. These findings suggest that soy husk could emerge as a potential hypoglycemic and anti-adipogenic nutraceutical in future. PRACTICAL APPLICATIONS: This was the first study to evaluate the potential effects of soy husk against the parameters of obese-diabetes in rats. In addition, promising effects derived from this study might explore the possibility of soy husk to be utilized as an antidiabetes nutraceutical.
format Article
author Tan, Seok Tyug
Ismail, Amin
Hamid, Muhajir
Chong, Pei Pei
Sun, Jian
spellingShingle Tan, Seok Tyug
Ismail, Amin
Hamid, Muhajir
Chong, Pei Pei
Sun, Jian
Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
author_facet Tan, Seok Tyug
Ismail, Amin
Hamid, Muhajir
Chong, Pei Pei
Sun, Jian
author_sort Tan, Seok Tyug
title Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
title_short Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
title_full Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
title_fullStr Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
title_full_unstemmed Soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of PPAR-gamma expression
title_sort soy husk extract improves physical and biochemicals parameters of obese-diabetic rats through the regulation of ppar-gamma expression
publisher Wiley-Blackwell Publishing
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/82217/1/Soy%20husk%20.pdf
http://psasir.upm.edu.my/id/eprint/82217/
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12843
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