Metallointercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition

• Main Authors: Yusoh, Nur Aininie, Leong, Sze Wei, Chia, Suet Lin, Harun, Siti Norain, Abdul Rahman, Mohd Basyaruddin, Vallis, Katherine A., Gill, Martin R., Ahmad, Haslina
• Format: Article
• Language: English
• Published: American Chemical Society 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/86732/1/Metallointercalator.pdf; http://psasir.upm.edu.my/id/eprint/86732/; https://pubs.acs.org/doi/full/10.1021/acschembio.9b00843
• Institution: Universiti Putra Malaysia

There is a need to improve and extend the use of clinically approved poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi), including for BRCA wild-type triple-negative breast cancer (TNBC). The demonstration that ruthenium(II) polypyridyl complex (RPC) metallointercalators can rapidly stall DNA rep...