Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application

Chemotherapy is the most common treatment for all cancer patients but this treatment poses many side effects due to lack of drug’s selectivity. To overcome this problem, utilizing a better and more effective delivery agent is the solution. Mesoporous silica nanoparticles (MSNs) emerged as a promisin...

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Main Authors: Zaharudin, Nurul Syahira, Mohamed Isa, Eleen Dayana, Ahmad, Haslina, Abdul Rahman, Mohd Basyaruddin, Jumbri, Khairulazhar
Format: Article
Language:English
Published: Elsevier 2020
Online Access:http://psasir.upm.edu.my/id/eprint/89085/1/SILICA.pdf
http://psasir.upm.edu.my/id/eprint/89085/
https://www.sciencedirect.com/science/article/pii/S131961032030003X
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Institution: Universiti Putra Malaysia
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spelling my.upm.eprints.890852021-09-01T22:04:51Z http://psasir.upm.edu.my/id/eprint/89085/ Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application Zaharudin, Nurul Syahira Mohamed Isa, Eleen Dayana Ahmad, Haslina Abdul Rahman, Mohd Basyaruddin Jumbri, Khairulazhar Chemotherapy is the most common treatment for all cancer patients but this treatment poses many side effects due to lack of drug’s selectivity. To overcome this problem, utilizing a better and more effective delivery agent is the solution. Mesoporous silica nanoparticles (MSNs) emerged as a promising platform in development of drug delivery agent. This is due to its desirable properties such as tunable pores, large surface area, good biocompatibility and easy functionalization. Furthermore, these properties can be tuned through the utilization of alternative template such as pyridinium ionic liquid. Besides, by employing surface functionalization, the effectiveness of MSNs as drug delivery agent may also increase. This work reported the usage of 1-hexadecylpyridinium bromide ionic liquid as template for MSNs production and the surface of MSNs was then further functionalized via post – grafting method in order to obtain MSN – NH2, MSN – SH and MSN – COOH as drug carrier, respectively. These functionalized MSNs were then used to study the drug loading and drug release of hydrophilic drug, gemcitabine and hydrophobic drug, quercetin. For quercetin, MSN-NH2 had the highest drug loading percentage (72%) and slowest release (14%) in 48 h while for gemcitabine, it was found that MSN-COOH had the highest drug loading percentage (45%) and slowest release (15%) in 48 h. Based on the results, it is suggested that mesoporous silica nanoparticle with surface functionalization has suitable properties for controlled drug release which gives constant release behavior over a period of time to avoid repeated administration of drug where the drug is administered at a fixed dosage and regular time interval. Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/89085/1/SILICA.pdf Zaharudin, Nurul Syahira and Mohamed Isa, Eleen Dayana and Ahmad, Haslina and Abdul Rahman, Mohd Basyaruddin and Jumbri, Khairulazhar (2020) Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application. Journal of Saudi Chemical Society, 24 (3). 289 - 302. ISSN 1319-6103 https://www.sciencedirect.com/science/article/pii/S131961032030003X 10.1016/j.jscs.2020.01.003
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Chemotherapy is the most common treatment for all cancer patients but this treatment poses many side effects due to lack of drug’s selectivity. To overcome this problem, utilizing a better and more effective delivery agent is the solution. Mesoporous silica nanoparticles (MSNs) emerged as a promising platform in development of drug delivery agent. This is due to its desirable properties such as tunable pores, large surface area, good biocompatibility and easy functionalization. Furthermore, these properties can be tuned through the utilization of alternative template such as pyridinium ionic liquid. Besides, by employing surface functionalization, the effectiveness of MSNs as drug delivery agent may also increase. This work reported the usage of 1-hexadecylpyridinium bromide ionic liquid as template for MSNs production and the surface of MSNs was then further functionalized via post – grafting method in order to obtain MSN – NH2, MSN – SH and MSN – COOH as drug carrier, respectively. These functionalized MSNs were then used to study the drug loading and drug release of hydrophilic drug, gemcitabine and hydrophobic drug, quercetin. For quercetin, MSN-NH2 had the highest drug loading percentage (72%) and slowest release (14%) in 48 h while for gemcitabine, it was found that MSN-COOH had the highest drug loading percentage (45%) and slowest release (15%) in 48 h. Based on the results, it is suggested that mesoporous silica nanoparticle with surface functionalization has suitable properties for controlled drug release which gives constant release behavior over a period of time to avoid repeated administration of drug where the drug is administered at a fixed dosage and regular time interval.
format Article
author Zaharudin, Nurul Syahira
Mohamed Isa, Eleen Dayana
Ahmad, Haslina
Abdul Rahman, Mohd Basyaruddin
Jumbri, Khairulazhar
spellingShingle Zaharudin, Nurul Syahira
Mohamed Isa, Eleen Dayana
Ahmad, Haslina
Abdul Rahman, Mohd Basyaruddin
Jumbri, Khairulazhar
Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
author_facet Zaharudin, Nurul Syahira
Mohamed Isa, Eleen Dayana
Ahmad, Haslina
Abdul Rahman, Mohd Basyaruddin
Jumbri, Khairulazhar
author_sort Zaharudin, Nurul Syahira
title Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
title_short Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
title_full Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
title_fullStr Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
title_full_unstemmed Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
title_sort functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
publisher Elsevier
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/89085/1/SILICA.pdf
http://psasir.upm.edu.my/id/eprint/89085/
https://www.sciencedirect.com/science/article/pii/S131961032030003X
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