Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies

• Main Authors: Mohd Faudzi, Siti Munirah, Abdullah, Maryam Aisyah, Abdull Manap, Mohd Rashidi, Ismail, Ahmad Zaidi, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Ramli, Aizi Nor Mazila, Abas, Faridah, Lajis, Nordin
• Format: Article
• Language: English
• Published: Elsevier 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/89396/1/NITRIC.pdf; http://psasir.upm.edu.my/id/eprint/89396/; https://www.sciencedirect.com/science/article/pii/S0045206819315214
• Institution: Universiti Putra Malaysia

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E2 (PGE2) suppression ability on IFN-γ/LPS-induced RAW 26...