K-ras peptide mimotope induces antigen specific Th1 and B-cell immune responses against G12A-mutated K-Ras antigen in balb/c mice

• Main Authors: Siak, Pui Yan, Wong, Kuan Yee, Song, Adelene Ai Lian, Abdul Rahim, Raha, Lian, Lionel Aun In
• Format: Article
• Published: Multidisciplinary Digital Publishing Institute 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/93999/; https://www.mdpi.com/2076-393X/9/3/195
• Institution: Universiti Putra Malaysia

KRAS G12A somatic point mutation in adenocarcinomas is categorized clinically as ineligibility criteria for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapies. In this study, a modified G12A-K-ras epitope (139A) with sequence-specific modifications to improve immunogenicity w...