Lipofection of single guide RNA targeting MMP8 decreases proliferation and migration in lung adenocarcinoma cells

• Main Authors: Maradiaga, Oscar David Hernandez, Mok, Pooi Ling, Sivapragasam, Gothai, Samrot, Antony V., Ali Khan, Mohammed Safwan, Aisha Farhana, Alzahrani, Badr, Tong, Jiabei, Karuppiah, Thilakavathy, S. Joseph, Narcisse M., Subbiah, Suresh Kumar
• Format: Article
• Published: MDPI AG 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/94040/; https://www.mdpi.com/1648-9144/57/7/710
• Institution: Universiti Putra Malaysia

Background and Objectives: Matrix metalloproteinases (MMP) have been implicated as major determinants of tumour growth and metastasis, which are considered two of the main hallmarks of cancer. The interaction of MMP8 and other signalling molecules within and adjacent tumoral tissues, including immun...