Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer

• Main Authors: Singh, Priya, Charles, Soniya, Madhavan, Thirumurthy, Munusamy-Ramanujam, Ganesh, Saraswathi, Nambiappan T., Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Arshad, Aziz, Arockiaraj, Jesu, Mala, Kanchana
• Format: Article
• Published: Elsevier BV 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/94569/; https://www.sciencedirect.com/science/article/pii/S0014299920307895
• Institution: Universiti Putra Malaysia

We investigated the role of protein arginine methylation (PAM) in estrogen receptor (ER)-positive breast cancer cells through pharmacological intervention. Tamoxifen (TAM) or adenosine dialdehyde (ADOX), independently, triggered cell cycle arrest and down-regulated PAM, as reduced protein arginine m...