Synthesis and optimization of mesoporous silica nanoparticles for ruthenium polypyridyl drug delivery

• Main Authors: Harun, Siti Norain, Ahmad, Haslina, Lim, Hong Ngee, Chia, Suet Lin, Gill, Martin R.
• Format: Article
• Published: MDPI AG 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/95261/; https://www.mdpi.com/1999-4923/13/2/150
• Institution: Universiti Putra Malaysia

The ruthenium polypyridyl complex [Ru(dppz)2PIP]2+ (dppz: dipyridophenazine, PIP: (2-(phenyl)-imidazo[4,5-f ][1,10]phenanthroline), or Ru-PIP, is a potential anticancer drug that acts by inhibiting DNA replication. Due to the poor dissolution of Ru-PIP in aqueous media, a drug delivery agent would b...