Synthesis of novel esters of mefenamic acid with pronounced anti-nociceptive effects and a proposed activity on GABA, opioid and glutamate receptors
Background: Mefenamic acid (MFA), a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), possesses a greater risk of dose-related central nervous system (CNS) toxicity than other NSAIDs. In this study, α-tocopherol and α-tocopherol acetate were selected as prodrug moieties for MFA in an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Elsevier BV
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95272/ https://www.sciencedirect.com/science/article/pii/S0928098721001664?via%3Dihub |
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| Institution: | Universiti Putra Malaysia |