The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children
This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtai...
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2021
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Online Access: | http://psasir.upm.edu.my/id/eprint/95499/1/The%20influence%20of%20traffic-related%20air%20pollution%20TRAP%20in%20primary%20schools%20and%20residential%20proximity%20to%20traffic%20sources%20on%20histone%20H3%20level%20in%20selected%20Malaysian%20children.pdf http://psasir.upm.edu.my/id/eprint/95499/ https://www.mdpi.com/1660-4601/18/15/7995 |
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my.upm.eprints.954992023-01-04T04:26:31Z http://psasir.upm.edu.my/id/eprint/95499/ The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM10, PM2.5, PM1, NO2, SO2, O3, CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM2.5-bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM10, PM2.5, PM1, BC, NO2, SO2, O3, CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area was more likely to get higher histone H3 levels (z = −5.13). There were positive weak correlations between histone H3 level and concentrations of NO2 (r = 0.37), CO (r = 0.36), PM1 (r = 0.35), PM2.5 (r = 0.34), SO2 (r = 0.34), PM10 (r = 0.33), O3 (r = 0.33), TVOC (r = 0.25), and BC (r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms. MDPI AG 2021-07-28 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95499/1/The%20influence%20of%20traffic-related%20air%20pollution%20TRAP%20in%20primary%20schools%20and%20residential%20proximity%20to%20traffic%20sources%20on%20histone%20H3%20level%20in%20selected%20Malaysian%20children.pdf Suhaimi, Nur Faseeha and Jalaludin, Juliana and Abu Bakar, Suhaili (2021) The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children. International Journal of Environmental Research and Public Health, 18 (7995). pp. 1-19. ISSN 1660-4601; ESSN: 1661-7827 https://www.mdpi.com/1660-4601/18/15/7995 10.3390/ijerph18157995 |
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This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM10, PM2.5, PM1, NO2, SO2, O3, CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM2.5-bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM10, PM2.5, PM1, BC, NO2, SO2, O3, CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area was more likely to get higher histone H3 levels (z = −5.13). There were positive weak correlations between histone H3 level and concentrations of NO2 (r = 0.37), CO (r = 0.36), PM1 (r = 0.35), PM2.5 (r = 0.34), SO2 (r = 0.34), PM10 (r = 0.33), O3 (r = 0.33), TVOC (r = 0.25), and BC (r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms. |
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Article |
author |
Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili |
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Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
author_facet |
Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili |
author_sort |
Suhaimi, Nur Faseeha |
title |
The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
title_short |
The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
title_full |
The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
title_fullStr |
The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
title_full_unstemmed |
The influence of traffic-related air pollution TRAP in primary schools and residential proximity to traffic sources on histone H3 level in selected Malaysian children |
title_sort |
influence of traffic-related air pollution trap in primary schools and residential proximity to traffic sources on histone h3 level in selected malaysian children |
publisher |
MDPI AG |
publishDate |
2021 |
url |
http://psasir.upm.edu.my/id/eprint/95499/1/The%20influence%20of%20traffic-related%20air%20pollution%20TRAP%20in%20primary%20schools%20and%20residential%20proximity%20to%20traffic%20sources%20on%20histone%20H3%20level%20in%20selected%20Malaysian%20children.pdf http://psasir.upm.edu.my/id/eprint/95499/ https://www.mdpi.com/1660-4601/18/15/7995 |
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