An immunoregulatory role for complement receptors in murine models of breast cancer

• Main Authors: Md Akhir, Fazrena Nadia, Mohd Noor, Mohd Hezmee, Weng, Keith Kit Leong, Nabizadeh, Jamileh A., Manthey, Helga D., Sonderegger, Stefan E, Nga, Jenny Ting Fung, McGirr, Crystal E, Shiels, Ian A., Mills, Paul C., Woodruff, Trent, Rolfe, Barbara
• Format: Article
• Published: Multidisciplinary Digital Publishing Institute 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/95856/; https://www.mdpi.com/2073-4468/10/1/2
• Institution: Universiti Putra Malaysia

The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors for complement proteins C3a (C3aR) and C5a (C5aR...