Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line

The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotu...

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Main Authors: Tan, Julia Meihua, Bullo, Saifullah, Fakurazi, Sharida, Hussein, Mohd Zobir
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/96359/
https://www.mdpi.com/2073-4360/13/9/1362
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Institution: Universiti Putra Malaysia
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spelling my.upm.eprints.963592023-01-30T06:55:05Z http://psasir.upm.edu.my/id/eprint/96359/ Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line Tan, Julia Meihua Bullo, Saifullah Fakurazi, Sharida Hussein, Mohd Zobir The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotubes (MWBA-CS), polyethylene glycol-multiwalled carbon nanotubes (MWBA-PG), Tween 20-multiwalled carbon nanotubes (MWBA-T2) and Tween 80-multiwalled carbon nanotubes (MWBA-T8). The physico-chemical properties of the modified nanocomposites were determined by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and Raman spectroscopy, while the surface morphology of the resulting nanocomposites was studied using field emission scanning electron microscopy (FESEM). All data revealed that the external surface of MWBA nanocomposites was successfully coated with the respective polymer molecules through hydrophobic and electrostatic interactions with improved thermal profiles. The cell viability assay, which was performed on cultured normal embryonic mouse fibroblast cells, confirmed their excellent biocompatibility in phosphate-buffered saline aqueous media. Overall, our findings herein suggest that the synthesized biopolymer-coated MWBA nanocomposites are promising nanomaterials for drug delivery applications as they enhance the solubility and dispersibility of CNT with significantly reduced cytotoxic effect, especially in normal cells. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Tan, Julia Meihua and Bullo, Saifullah and Fakurazi, Sharida and Hussein, Mohd Zobir (2021) Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line. Polymer, 13 (9). art. no. 1362. pp. 1-18. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/9/1362 10.3390/polym13091362
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotubes (MWBA-CS), polyethylene glycol-multiwalled carbon nanotubes (MWBA-PG), Tween 20-multiwalled carbon nanotubes (MWBA-T2) and Tween 80-multiwalled carbon nanotubes (MWBA-T8). The physico-chemical properties of the modified nanocomposites were determined by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and Raman spectroscopy, while the surface morphology of the resulting nanocomposites was studied using field emission scanning electron microscopy (FESEM). All data revealed that the external surface of MWBA nanocomposites was successfully coated with the respective polymer molecules through hydrophobic and electrostatic interactions with improved thermal profiles. The cell viability assay, which was performed on cultured normal embryonic mouse fibroblast cells, confirmed their excellent biocompatibility in phosphate-buffered saline aqueous media. Overall, our findings herein suggest that the synthesized biopolymer-coated MWBA nanocomposites are promising nanomaterials for drug delivery applications as they enhance the solubility and dispersibility of CNT with significantly reduced cytotoxic effect, especially in normal cells.
format Article
author Tan, Julia Meihua
Bullo, Saifullah
Fakurazi, Sharida
Hussein, Mohd Zobir
spellingShingle Tan, Julia Meihua
Bullo, Saifullah
Fakurazi, Sharida
Hussein, Mohd Zobir
Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
author_facet Tan, Julia Meihua
Bullo, Saifullah
Fakurazi, Sharida
Hussein, Mohd Zobir
author_sort Tan, Julia Meihua
title Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
title_short Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
title_full Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
title_fullStr Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
title_full_unstemmed Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
title_sort characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on nih/3t3 cell line
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/96359/
https://www.mdpi.com/2073-4360/13/9/1362
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