Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

• Main Authors: Teo, Michelle Yee Mun, Ng, Jeremy Jeack Ceen, Jung, Yin Fong, Jung, Shan Hwang, Song, Adelene Ai Lian, Lim, Renee Lay Hong, In, Lionel Lian Aun
• Format: Article
• Language: English
• Published: PeerJ Publishing 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/96690/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/96690/; https://peerj.com/articles/11063/
• Institution: Universiti Putra Malaysia

Background: KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype, thus reinforcing the need towards the development of target...