Discovery of new inhibitor for the protein arginine deiminase type 4 (PAD4) by rational design of α-enolase-derived peptides
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 0.24 % of the world population. Protein arginine deiminase type 4 (PAD4) is believed to be responsible for the occurrence of RA by catalyzing citrullination of proteins. The citrullinated proteins act as autoantigens by...
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Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021
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Online Access: | http://psasir.upm.edu.my/id/eprint/96755/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/96755/ https://www.sciencedirect.com/science/article/pii/S1476927121000542 |
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Institution: | Universiti Putra Malaysia |
Language: | English |