Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry
This study aimed to assess the association of exposure to particle-bound (PM2.5) polycyclic aromatic hydrocarbons (PAHs) with potential genotoxicity and cancer risk among children living near the petrochemical industry and comparative populations in Malaysia. PM2.5 samples were collected using a low...
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Multidisciplinary Digital Publishing Institute
2021
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Online Access: | http://psasir.upm.edu.my/id/eprint/97235/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/97235/ https://www.mdpi.com/1660-4601/18/5/2575 |
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my.upm.eprints.972352022-09-12T08:41:51Z http://psasir.upm.edu.my/id/eprint/97235/ Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry Sopian, Nor Ashikin Jalaludin, Juliana Abu Bakar @ Jamaludin, Suhaili Hamedon, Titi Rahmawati Latif, Mohd Talib This study aimed to assess the association of exposure to particle-bound (PM2.5) polycyclic aromatic hydrocarbons (PAHs) with potential genotoxicity and cancer risk among children living near the petrochemical industry and comparative populations in Malaysia. PM2.5 samples were collected using a low-volume sampler for 24 h at three primary schools located within 5 km of the industrial area and three comparative schools more than 20 km away from any industrial activity. A gas chromatography–mass spectrometer was used to determine the analysis of 16 United States Environmental Protection Agency (USEPA) priority PAHs. A total of 205 children were randomly selected to assess the DNA damage in buccal cells, employing the comet assay. Total PAHs measured in exposed and comparative schools varied, respectively, from 61.60 to 64.64 ng m−3 and from 5.93 to 35.06 ng m−3. The PAH emission in exposed schools was contributed mainly by traffic and industrial emissions, dependent on the source apportionment. The 95th percentiles of the incremental lifetime cancer risk estimated using Monte Carlo simulation revealed that the inhalation risk for the exposed children and comparative populations was 2.22 × 10−6 and 2.95 × 10−7, respectively. The degree of DNA injury was substantially more severe among the exposed children relative to the comparative community. This study reveals that higher exposure to PAHs increases the risk of genotoxic effects and cancer among children. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97235/1/ABSTRACT.pdf Sopian, Nor Ashikin and Jalaludin, Juliana and Abu Bakar @ Jamaludin, Suhaili and Hamedon, Titi Rahmawati and Latif, Mohd Talib (2021) Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry. International Journal of Environmental Research and Public Health, 18 (5). art. no. 2575. pp. 1-20. ISSN 1660-4601 https://www.mdpi.com/1660-4601/18/5/2575 10.3390/ijerph18052575 |
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This study aimed to assess the association of exposure to particle-bound (PM2.5) polycyclic aromatic hydrocarbons (PAHs) with potential genotoxicity and cancer risk among children living near the petrochemical industry and comparative populations in Malaysia. PM2.5 samples were collected using a low-volume sampler for 24 h at three primary schools located within 5 km of the industrial area and three comparative schools more than 20 km away from any industrial activity. A gas chromatography–mass spectrometer was used to determine the analysis of 16 United States Environmental Protection Agency (USEPA) priority PAHs. A total of 205 children were randomly selected to assess the DNA damage in buccal cells, employing the comet assay. Total PAHs measured in exposed and comparative schools varied, respectively, from 61.60 to 64.64 ng m−3 and from 5.93 to 35.06 ng m−3. The PAH emission in exposed schools was contributed mainly by traffic and industrial emissions, dependent on the source apportionment. The 95th percentiles of the incremental lifetime cancer risk estimated using Monte Carlo simulation revealed that the inhalation risk for the exposed children and comparative populations was 2.22 × 10−6 and 2.95 × 10−7, respectively. The degree of DNA injury was substantially more severe among the exposed children relative to the comparative community. This study reveals that higher exposure to PAHs increases the risk of genotoxic effects and cancer among children. |
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Article |
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Sopian, Nor Ashikin Jalaludin, Juliana Abu Bakar @ Jamaludin, Suhaili Hamedon, Titi Rahmawati Latif, Mohd Talib |
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Sopian, Nor Ashikin Jalaludin, Juliana Abu Bakar @ Jamaludin, Suhaili Hamedon, Titi Rahmawati Latif, Mohd Talib Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
author_facet |
Sopian, Nor Ashikin Jalaludin, Juliana Abu Bakar @ Jamaludin, Suhaili Hamedon, Titi Rahmawati Latif, Mohd Talib |
author_sort |
Sopian, Nor Ashikin |
title |
Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
title_short |
Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
title_full |
Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
title_fullStr |
Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
title_full_unstemmed |
Exposure to particulate PAHs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
title_sort |
exposure to particulate pahs on potential genotoxicity and cancer risk among school children living near the petrochemical industry |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
http://psasir.upm.edu.my/id/eprint/97235/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/97235/ https://www.mdpi.com/1660-4601/18/5/2575 |
_version_ |
1744355315573325824 |