Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

• Main Authors: Mohd-Zahid, Manali Haniti, Zulkifli, Siti Nadiah, Che Abdullah, Che Azurahanim, Lim, Jit Kang, Fakurazi, Sharida, Kah, Keng Wong, Zakaria, Andee Dzulkarnaen, Ismail, Norzila, Uskoković, Vuk, Mohamud, Rohimah, Zakaria, Zukarnain
• Format: Article
• Language: English
• Published: RSC Publishing 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/97460/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/97460/; https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra01093j
• Institution: Universiti Putra Malaysia

The enhanced permeability and retention effect allows for passive targeting of solid tumours by nanoparticles carrying anticancer drugs. However, active targeting by incorporation of various ligands onto nanoparticles can provide for a more selective and enhanced chemotherapeutic effect and compleme...