Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats

Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% m...

Full description

Saved in:
Bibliographic Details
Main Authors: Osman, Nur Maziah Hanum, Mohd Yusof, Barakatun Nisak, Jeevetha, Subramaniam, Ismail, Amin, Azlan, Azrina, Goh, Yong Meng, Kamaruddin, Nor Azmi, Wakisaka, Minato
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
Online Access:http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf
http://psasir.upm.edu.my/id/eprint/98110/
https://medic.upm.edu.my/upload/dokumen/2022011912065031_MJMHS_1154.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Universiti Putra Malaysia
Language: English
id my.upm.eprints.98110
record_format eprints
spelling my.upm.eprints.981102022-08-11T03:44:52Z http://psasir.upm.edu.my/id/eprint/98110/ Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats Osman, Nur Maziah Hanum Mohd Yusof, Barakatun Nisak Jeevetha, Subramaniam Ismail, Amin Azlan, Azrina Goh, Yong Meng Kamaruddin, Nor Azmi Wakisaka, Minato Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% moderate-CHO (MCHO, n=8) and 65% High-CHO (HCHO, n=8)) or high-fat diet (HFD, n=8) were compared with rats maintained on standard pellet diet (SD, n=8) for eight weeks period. Carbohydrate sources in the HFD and SD were mainly based on cornstarch (25% of amylose). Outcomes measures include body weight and metabolic parameters. Results: At baseline, body weight and metabolic parameters (fasting plasma glucose, insulin, and triglyceride levels) were comparable in all rats. Despite higher daily caloric intake in rats fed with HFD (103.9±3.0) than the other diets, no significant differences in body weight between groups after 8 weeks of study. However, rats’ feds with WR-based CHO diets (both moderate and high carbohydrates) had higher fasting blood glucose (MCHO=12.8±1.6, HCHO=16.9±2.4) and triglycerides level (MCHO=1.2±0.0, HCHO=1.3±0.0) than rats in cornstarch-based HFD and SD (p <0.05). Both HFD and HCHO had higher fasting insulin than MCHO and SD (p<0.05), but the homeostatic model assessment of insulin resistance (HOMA-IR) was significantly higher in WR-based CHO diets (both moderate and high carbohydrates) than the rats in cornstarch-based HFD and SD (p<0.05). Conclusion: A WR-based CHO diet exhibits higher fasting blood glucose, triglycerides, and insulin resistance state than a high-fat diet without a significant impact on body weight. These findings may explain the growing incidence of diabetes in Asia and worth studying further. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf Osman, Nur Maziah Hanum and Mohd Yusof, Barakatun Nisak and Jeevetha, Subramaniam and Ismail, Amin and Azlan, Azrina and Goh, Yong Meng and Kamaruddin, Nor Azmi and Wakisaka, Minato (2022) Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats. Malaysian Journal of Medicine and Health Sciences, 18 (1). pp. 234-240. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022011912065031_MJMHS_1154.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% moderate-CHO (MCHO, n=8) and 65% High-CHO (HCHO, n=8)) or high-fat diet (HFD, n=8) were compared with rats maintained on standard pellet diet (SD, n=8) for eight weeks period. Carbohydrate sources in the HFD and SD were mainly based on cornstarch (25% of amylose). Outcomes measures include body weight and metabolic parameters. Results: At baseline, body weight and metabolic parameters (fasting plasma glucose, insulin, and triglyceride levels) were comparable in all rats. Despite higher daily caloric intake in rats fed with HFD (103.9±3.0) than the other diets, no significant differences in body weight between groups after 8 weeks of study. However, rats’ feds with WR-based CHO diets (both moderate and high carbohydrates) had higher fasting blood glucose (MCHO=12.8±1.6, HCHO=16.9±2.4) and triglycerides level (MCHO=1.2±0.0, HCHO=1.3±0.0) than rats in cornstarch-based HFD and SD (p <0.05). Both HFD and HCHO had higher fasting insulin than MCHO and SD (p<0.05), but the homeostatic model assessment of insulin resistance (HOMA-IR) was significantly higher in WR-based CHO diets (both moderate and high carbohydrates) than the rats in cornstarch-based HFD and SD (p<0.05). Conclusion: A WR-based CHO diet exhibits higher fasting blood glucose, triglycerides, and insulin resistance state than a high-fat diet without a significant impact on body weight. These findings may explain the growing incidence of diabetes in Asia and worth studying further.
format Article
author Osman, Nur Maziah Hanum
Mohd Yusof, Barakatun Nisak
Jeevetha, Subramaniam
Ismail, Amin
Azlan, Azrina
Goh, Yong Meng
Kamaruddin, Nor Azmi
Wakisaka, Minato
spellingShingle Osman, Nur Maziah Hanum
Mohd Yusof, Barakatun Nisak
Jeevetha, Subramaniam
Ismail, Amin
Azlan, Azrina
Goh, Yong Meng
Kamaruddin, Nor Azmi
Wakisaka, Minato
Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
author_facet Osman, Nur Maziah Hanum
Mohd Yusof, Barakatun Nisak
Jeevetha, Subramaniam
Ismail, Amin
Azlan, Azrina
Goh, Yong Meng
Kamaruddin, Nor Azmi
Wakisaka, Minato
author_sort Osman, Nur Maziah Hanum
title Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
title_short Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
title_full Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
title_fullStr Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
title_full_unstemmed Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
title_sort effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf
http://psasir.upm.edu.my/id/eprint/98110/
https://medic.upm.edu.my/upload/dokumen/2022011912065031_MJMHS_1154.pdf
_version_ 1743108554399678464