Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants

Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants

Erythrocytes require glucose-6-phosphate dehydrogenase (G6PD) to generate NADPH and protect themselves against hemolytic anemia induced by oxidative stress. Peroxiredoxin 2 (Prx2) is a major antioxidant enzyme that requires NADPH to recycle its oxidized (disulfide-bonded) form. Our aims were to dete...

Full description

Saved in:
Bibliographic Details
Main Authors: Fook-Choe, Cheah, Fei-Liang, Wong, Azlin, Ithnin, Alexander V., Peskin, Christine C, Winterbourn, Ainoon, Othman
Format: Article
Language:English
Published: Federation Amer Soc Exp Biol 2015
Subjects:
Hemolytic Anemia
Antioxidant Defense
Hydrogen Peroxide
Online Access:http://ddms.usim.edu.my/handle/123456789/8290
http://www.fasebj.org/content/28/7/3205.full.pdf+html?sid=fe49b0d9-ac36-404e-b08c-592bc0526eb5
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Universiti Sains Islam Malaysia
Language: English

Internet

http://ddms.usim.edu.my/handle/123456789/8290
http://www.fasebj.org/content/28/7/3205.full.pdf+html?sid=fe49b0d9-ac36-404e-b08c-592bc0526eb5

Similar Items