Oxidant-specific regulation of protein synthesis in Candida albicans

• Main Authors: Arunkumar, Sundaram, Chris M., Grant
• Format: Article
• Language: English
• Published: Academic Press Inc Elsevier Science 2015
• Subjects: Candida albicans; Oxidative stress; Gcn2; Gcn4; Translational regulation
• Online Access: http://ddms.usim.edu.my/handle/123456789/8336
• Institution: Universiti Sains Islam Malaysia

Eukaryotic cells typically respond to stress conditions by inhibiting global protein synthesis. The initiation phase is the main target of regulation and represents a key control point for eukaryotic gene expression. In Saccharomyces cerevisiae and mammalian cells this is achieved by phosphorylation...