Co-inheritance of compound heterozygous Hb constant spring and a single -α 3.7 gene deletion with heterozygous δβ thalassaemia: A diagnostic challenge

• Main Authors: R.Z., Azma, A., Othman, N., Azman, H., Alauddin, A., Ithnin, N., Yusof, N.F., Razak, N.H., Sardi, N.H., Hussin
• Format: Article
• Language: en_US
• Published: 2015
• Subjects: α +thalassaemia ; δβ; Capillary electrophoresis; Hb constant spring; Molecular analysis; Thalassaemia
• Online Access: http://ddms.usim.edu.my/handle/123456789/8731
• Institution: Universiti Sains Islam Malaysia

Haemoglobin Constant Spring (Hb CS) mutation and single gene deletions are common underlying genetic abnormalities for alpha thalassaemias. Co-inheritance of deletional and non-deletional alpha (α) thalassaemias may result in various thalassaemia syndromes. Concomitant co-inheritance with beta (β) a...