α1-Adrenoceptors And At1 Receptors In The Modulation Of Renal Hemodynamics In High Salt And Doca Models Of Hypertensive Rats Treated With Tempol And Losartan
Hipertensi merupakan penyebab utama morbiditi dan kematian yang berkait rapat dengan kerosakan ginjal. Pengambilan garam lebihan menyumbang kepada pathogenesis hipertensi. Reseptor adrenergik-α1 menyumbang kepada modulasi nada vaskular ginjal untuk mengawal tekanan darah. Hypertension is a ma...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/32669/1/Yen_Pei_Pei.pdf http://eprints.usm.my/32669/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Hipertensi merupakan penyebab utama morbiditi dan kematian yang berkait
rapat dengan kerosakan ginjal. Pengambilan garam lebihan menyumbang kepada
pathogenesis hipertensi. Reseptor adrenergik-α1 menyumbang kepada modulasi nada
vaskular ginjal untuk mengawal tekanan darah.
Hypertension is a major cause of morbidity and mortality from renal
impairment. An increase of sodium intake contributes to the pathogenesis of
hypertension. α1-adrenoceptors modulate renal vascular tone in the regulation of
blood pressure. This study was undertaken to investigate the effects of tempol and
losartan on renal function and haemodynamics in Sprague Dawley (SD) rats fed with
normal diet, SD rats fed with high sodium diet, DOCA-salt treated rats fed with
normal diet and DOCA-salt treated rats fed with high sodium diet. |
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