Contribution of a1-adrenoceptor subtypes in renal hemodynamics and functions of rats with renal impairment : alteration of g-protien linked to shift in the functionality And expression of renal a1-adrenoceptor subtypes.

• Main Author: Abdul Sattar, Munavvar Zubaid
• Format: Monograph
• Published: Universiti Sains Malaysia 2013
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/32811/
• Institution: Universiti Sains Malaysia

This study investigated the role of a 1-adrenoceptors subtypes in the regulation of renal haeamodynamics at the level of renal resistance vasculature. It is hypothesized that a 1- adrenoceptor subtype(s) distribution depends on pathophysiological states of animal. Thus, the functional role of a 1-adrenoceptor subtype(s) on renal haeamodynamics of rats with renal failure, diabetic nephropathy and cardiac hypertrophy was investigated along with the Go proteins expression in the kidney and heart of normal rats and that of rats with impairments. Kajian ini menyiasat peranan adrenoseptor subjenis a1 dalam pengawalaturan hemodinamik ginjal di peringkat rintangan vaskulatur ginjal. Adalah dihipotesis bahawa distribusi adrenoseptor subjenis a1 bergantung kepada keadaan patofisiologi haiwan. Oleh itu, peranan fungsi adrenoseptor subjenisa 1 ke atas hemodinamik ginjaJ telah dikaji dalam tikus dengan kegagalan buah pinggang, nefropati diabetes dan hipertropi jantung bersama-sama dengan ungkapan protein Go dalam buah pinggang dan hati tikus biasa dan tikus dengan kecacatan.