Immunoregulatory effects of recombinant BCG (rBCG) expressing c-terminus of merozoite surface protein-1 (MSP-1C) of Plasmodium falciparum on mouse macrophage

• Main Author: Mohamad, Dhaniah
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: R5-130.5 General works
• Online Access: http://eprints.usm.my/36407/1/Dr._Dhaniah_Mohamad_TSTZ_%28NN24%29.pdf; http://eprints.usm.my/36407/
• Institution: Universiti Sains Malaysia

Fagositosis oleh makrofaj adalah mekanisme pertahanan pertama terhadap jangkitan parasit malaria dalam sistem imun semula jadi. Setelah diaktifkan, makrofaj akan bertindak sebagai sel radang dan sel anti-mikrob melalui rembesan sitokin pro-inflamatori dan nitrik oksida (NO). Dalam kajian ini, kesan immunoregulatori klon BCG rekombinan (rBCG) yang mengekspreskan terminus C protein permukaan merozoite-1 19-kDa (MSP-1C) daripada Plasmodium falciparum ke atas sel makrofaj mencit, J774A.1 telah dikaji. Macrophage phagocytosis acts as the first line of defence against malaria parasites infection in the innate immune system. Once activated, macrophages act as inflammatory and microbicidal cells through the production of pro-inflammatory cytokines and nitric oxide (NO). In this study, the immunoregulatory effects of a recombinant BCG (rBCG) clone expressing the 19-kDa C-terminus of the merozoite surface protein-1 (MSP-1C) of Plasmodium falciparum was examined on the mouse macrophage cell line J774A.1.