3,5-Bis(arylidene)-4-piperidonesaspotential dengue proteaseinhibitors

• Main Authors: Osman, Hasnah, Idris, Nor Hashima, Kamarulzaman, Ezatul Ezleen, A.Wahab, Habibah, Hassan, Mohd. Zaheen
• Format: Article
• Published: Elsevier 2017
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/36660/; http://dx.doi.org/10.1016/j.apsb.2017.04.009
• Institution: Universiti Sains Malaysia

Dengue isaseveremosquito-borneviralinfectioncausinghalfamilliondeathsannually. Dengue virusNS2B/NS3proteaseisavalidatedtargetforanti-denguedrugdesign.Aseriesofhitherto unreported 3,5-bis(arylidene)-4-piperidonesanalogues 4a–4j were synthesizedandscreened in silico against DENV2NS2B/NS3proteasetoe...