The cellular toxicology of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth

• Main Authors: Saidin, Nor Aini, Holmes, Elaine, Takayama, Hiromitsu, Gooderham, Nigel J.
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2015
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/37710/1/SaidinToxRes2015PREPRINT.pdf; http://eprints.usm.my/37710/; http://pubs.rsc.org/-/content/getauthorversionpdf/C5TX00113G
• Institution: Universiti Sains Malaysia

Mitragyna speciosa Korth (Kratom), a herb of the Rubiaceae family is indigenous to southeast Asia. The plant and its dominant alkaloid mitragynine (MIT) are narcotic/analgesic and illicit consumption is widespread in Asia; the toxicological consequences of consumption are poorly documented. We det...