Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients
In Malaysia, breast cancer is the most frequent type of disease among women. This study was designed to determine the clinical usefulness of carbohydrate antigen (CA 15-3) and interleukin 2 (IL-2) levels as combined biomarkers in monitoring breast cancer patient’s response to chemotherapy. Ethica...
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my.usm.eprints.37894 http://eprints.usm.my/37894/ Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients Abdul Hameed, Ahmed Muthanna Abdul Hamid, Auni Fatin Noor, Nurul Shahfiza Appalanaido, Gokula Kumar Sahul Hamid, Shahrul Bariyah RC31-1245 Internal medicine In Malaysia, breast cancer is the most frequent type of disease among women. This study was designed to determine the clinical usefulness of carbohydrate antigen (CA 15-3) and interleukin 2 (IL-2) levels as combined biomarkers in monitoring breast cancer patient’s response to chemotherapy. Ethical approval was obtained to recruit patients with histologically confirmed invasive ductal carcinoma (IDC) attending Oncology Clinic at Advanced Medical and Dental Institute. Whole blood was collected from 10 IDC breast cancer patients’ pre and post primary chemotherapy. Plasma was separated from the whole blood to determine the CA 15-3 level and IL-2 level using enzyme-linked immunosorbent assay (ELISA) pre and posttreatment. In addition, the histological findings, tumour stage and other patients’ data were obtained from the medical record. Findings showed that IL-2 had borderline significant changes between pre- and post-chemotherapy (p = 0.074) whereas for CA 15-3, there was insignificant differences of CA 15-3 level between pre and post-chemotherapy (p > 0.05). It was noted that only CA 15-3 level had significant correlation with tumour size. This study demonstrates that IL-2 level requires further investigation in a larger sample size to correlate its potential use as combined biomarker with CA 15-3 in monitoring response to chemotherapy. IOP Publishing 2017 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37894/1/Study_on_IL-2_and_CA_15-3_level_as_combined_biomar.pdf Abdul Hameed, Ahmed Muthanna and Abdul Hamid, Auni Fatin and Noor, Nurul Shahfiza and Appalanaido, Gokula Kumar and Sahul Hamid, Shahrul Bariyah (2017) Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients. Journal of Physics: Conference Series, 851 (1). pp. 1-7. ISSN 1742-6588 http://iopscience.iop.org/article/10.1088/1742-6596/851/1/012038 |
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RC31-1245 Internal medicine Abdul Hameed, Ahmed Muthanna Abdul Hamid, Auni Fatin Noor, Nurul Shahfiza Appalanaido, Gokula Kumar Sahul Hamid, Shahrul Bariyah Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
description |
In Malaysia, breast cancer is the most frequent type of disease among women. This
study was designed to determine the clinical usefulness of carbohydrate antigen (CA 15-3) and
interleukin 2 (IL-2) levels as combined biomarkers in monitoring breast cancer patient’s
response to chemotherapy. Ethical approval was obtained to recruit patients with histologically
confirmed invasive ductal carcinoma (IDC) attending Oncology Clinic at Advanced Medical
and Dental Institute. Whole blood was collected from 10 IDC breast cancer patients’ pre and
post primary chemotherapy. Plasma was separated from the whole blood to determine the CA
15-3 level and IL-2 level using enzyme-linked immunosorbent assay (ELISA) pre and posttreatment.
In addition, the histological findings, tumour stage and other patients’ data were
obtained from the medical record. Findings showed that IL-2 had borderline significant
changes between pre- and post-chemotherapy (p = 0.074) whereas for CA 15-3, there was
insignificant differences of CA 15-3 level between pre and post-chemotherapy (p > 0.05). It
was noted that only CA 15-3 level had significant correlation with tumour size. This study
demonstrates that IL-2 level requires further investigation in a larger sample size to correlate its
potential use as combined biomarker with CA 15-3 in monitoring response to chemotherapy. |
format |
Article |
author |
Abdul Hameed, Ahmed Muthanna Abdul Hamid, Auni Fatin Noor, Nurul Shahfiza Appalanaido, Gokula Kumar Sahul Hamid, Shahrul Bariyah |
author_facet |
Abdul Hameed, Ahmed Muthanna Abdul Hamid, Auni Fatin Noor, Nurul Shahfiza Appalanaido, Gokula Kumar Sahul Hamid, Shahrul Bariyah |
author_sort |
Abdul Hameed, Ahmed Muthanna |
title |
Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
title_short |
Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
title_full |
Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
title_fullStr |
Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
title_full_unstemmed |
Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
title_sort |
study on il-2 and ca 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients |
publisher |
IOP Publishing |
publishDate |
2017 |
url |
http://eprints.usm.my/37894/1/Study_on_IL-2_and_CA_15-3_level_as_combined_biomar.pdf http://eprints.usm.my/37894/ http://iopscience.iop.org/article/10.1088/1742-6596/851/1/012038 |
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