Chemical Constituents and Biological Activities of Strobilanthes crispus L.
Phytochemical investigation of Strobilanthes crispus has led to the isolation of 1-heptacosanol (1), tetracosanoic acid (2), stigmasterol (3) from the hexane extract, a mixture of four C20-C24 fatty acid esters of �- amyrin (4), taraxerol (5), taraxerone (6), a mixture of two C22 and C24 fatty aci...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ACG Publications
2013
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38439/1/Chemical_Constituents_and_Biological_Activities_of.pdf http://eprints.usm.my/38439/ http://www.acgpubs.org/RNP/2013/Volume7/Issue%201/9-RNP-1204-61.pdf |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Phytochemical investigation of Strobilanthes crispus has led to the isolation of 1-heptacosanol (1),
tetracosanoic acid (2), stigmasterol (3) from the hexane extract, a mixture of four C20-C24 fatty acid esters of �-
amyrin (4), taraxerol (5), taraxerone (6), a mixture of two C22 and C24 fatty acid esters of taraxerol (7) from the
dichloromethane extract, 4-acetyl-2,7-dihydroxy-1,4,8-triphenyloctane-3,5-dione (8) and stigmasterol �-Dglucopyranoside
(9) from the methanol extract. The dichloromethane and methanol crude extracts together with
the isolated compounds (4-9) were tested for antibacterial activity using the determination of minimum
inhibitory concentration assay and acetylcholinesterase inhibitory activity using the micro-plate assay. The
majority of the samples tested indicated good activity against the Gram-positive bacteria (7.8�125.0 μg/mL),
and moderate to weak activity against the Gram-negative bacteria (31.0�250.0 μg/mL) employed. Moderate to
weak activity was observed against acetylcholinesterase. Compound (8) showed excellent antibacterial activity
against Bacillus subtilis and Staphylococcus aureus, with MIC values of 15.6 and 7.8 μg/mL, respectively, and
significant activity against Escherichia coli and Salmonella typhimurium, with MIC values of 62.5 and 31.0
μg/mL, respectively. Compound (8) also showed the highest acetylcholinesterase inhibitory activity, with an IC50
value of 31.0 μg/mL. This is the first report describing the antibacterial and acetylcholinesterase inhibitory
activities of S. crispus on the basis of the isolated constituents. This research work has provided scientific proof
of the traditional medicinal use of the leaves of S. crispus. |
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