Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers

Objective. We studied the clinicopathological parameters of adenocarcinoma arising from endocervix (ECA) and from endometrium (EMA) based on the expression of P16ink4a, P21waf1, and p27Kip1 proteins. Study Design. Immunohistochemistry was done on sections of confirmed ECA and EMA from hysterectomy...

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Main Authors: Abu Backer, Farveen Marican, Nik Mustapha, Nik Raihan, Othman, Nor Hayati
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2011
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Online Access:http://eprints.usm.my/38457/1/Clinicopathological_Comparison_of_Adenocarcinoma_of_Cervix_and_Endometrium.pdf
http://eprints.usm.my/38457/
https://doi.org/10.1155/2011/857851
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Institution: Universiti Sains Malaysia
Language: English
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spelling my.usm.eprints.38457 http://eprints.usm.my/38457/ Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers Abu Backer, Farveen Marican Nik Mustapha, Nik Raihan Othman, Nor Hayati RB Pathology Objective. We studied the clinicopathological parameters of adenocarcinoma arising from endocervix (ECA) and from endometrium (EMA) based on the expression of P16ink4a, P21waf1, and p27Kip1 proteins. Study Design. Immunohistochemistry was done on sections of confirmed ECA and EMA from hysterectomy specimens which have had no prior chemotherapy/ radiotherapy. Results. There were 40 ECAs and 92 EMAs. The mean age of ECA was 49.82 (SD 10.29); the youngest was 30 years old and the oldest 75 years old. The mean age of EMA was 54.45 (SD 10.92); the youngest was 30 years old and the oldest was 82 years old. For ECA, the size of the tumour is significantly associated with age and with depth of infiltration. FIGO stage is associated with histological grade. p21WAF1 expression is significantly associated with infiltration of the corpus and lymph node metastasis. p27Kip1 expression is significantly associated with lymph node invasion. The presence of lymph node metastasis is strongly associated when p16INK4a and p27Kip1 expressions are analyzed in combination. For EMA, p16INK4a expression is associated with histologic grade. Conclusion. Our study shows that we could use these cell cycle markers as predictors for more aggressive subsets of adenocarcinoma of the cervix and endometrium. Hindawi Publishing Corporation 2011 Article PeerReviewed application/pdf en http://eprints.usm.my/38457/1/Clinicopathological_Comparison_of_Adenocarcinoma_of_Cervix_and_Endometrium.pdf Abu Backer, Farveen Marican and Nik Mustapha, Nik Raihan and Othman, Nor Hayati (2011) Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers. Infectious Diseases in Obstetrics and Gynecology, 2011 (857851). pp. 1-6. ISSN 1064-7449 https://doi.org/10.1155/2011/857851
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RB Pathology
spellingShingle RB Pathology
Abu Backer, Farveen Marican
Nik Mustapha, Nik Raihan
Othman, Nor Hayati
Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
description Objective. We studied the clinicopathological parameters of adenocarcinoma arising from endocervix (ECA) and from endometrium (EMA) based on the expression of P16ink4a, P21waf1, and p27Kip1 proteins. Study Design. Immunohistochemistry was done on sections of confirmed ECA and EMA from hysterectomy specimens which have had no prior chemotherapy/ radiotherapy. Results. There were 40 ECAs and 92 EMAs. The mean age of ECA was 49.82 (SD 10.29); the youngest was 30 years old and the oldest 75 years old. The mean age of EMA was 54.45 (SD 10.92); the youngest was 30 years old and the oldest was 82 years old. For ECA, the size of the tumour is significantly associated with age and with depth of infiltration. FIGO stage is associated with histological grade. p21WAF1 expression is significantly associated with infiltration of the corpus and lymph node metastasis. p27Kip1 expression is significantly associated with lymph node invasion. The presence of lymph node metastasis is strongly associated when p16INK4a and p27Kip1 expressions are analyzed in combination. For EMA, p16INK4a expression is associated with histologic grade. Conclusion. Our study shows that we could use these cell cycle markers as predictors for more aggressive subsets of adenocarcinoma of the cervix and endometrium.
format Article
author Abu Backer, Farveen Marican
Nik Mustapha, Nik Raihan
Othman, Nor Hayati
author_facet Abu Backer, Farveen Marican
Nik Mustapha, Nik Raihan
Othman, Nor Hayati
author_sort Abu Backer, Farveen Marican
title Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
title_short Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
title_full Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
title_fullStr Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
title_full_unstemmed Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
title_sort clinicopathological comparison of adenocarcinoma of cervix and endometrium using cell cyclemarkers: p16ink4a, p21waf1, and p27kip1 on 132 cancers
publisher Hindawi Publishing Corporation
publishDate 2011
url http://eprints.usm.my/38457/1/Clinicopathological_Comparison_of_Adenocarcinoma_of_Cervix_and_Endometrium.pdf
http://eprints.usm.my/38457/
https://doi.org/10.1155/2011/857851
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