Cu(II) complexes of 2-(diphenylmethylene) hydrazinecarboxamide derivatives: Synthesis, characterization and antifungal activity against Fusarium oxysporum f. sp. cubense tropical race 4

• Main Authors: Yi, Chen Chan, Mohamed Ali, Abdussalam Salhin, Salleh, Baharuddin, Rosli, Hafizi, Ching, Kheng Quah
• Format: Article
• Published: Elsevier 2017
• Subjects: QC1-999 Physics; QD1-999 Chemistry; QH1 Natural history (General - Including nature conservation, geographical distribution)
• Online Access: http://eprints.usm.my/38596/; http://dx.doi.org/10.1016/j.arabjc.2014.02.014
• Institution: Universiti Sains Malaysia

The semi- and thiosemicarbazones of benzophenone derivatives (L1–L6) had been synthesized and their respective Cu(II) complexes (1–6) were obtained as precipitates by interaction with CuCl2 in ethanolic solution. All these compounds were characterized by 1H and 13C NMR, IR, UV–Vis and elemental analysis (CHN). The structures of L1 and L4 were further elucidated by Xray crystallography. Antifungal activities of the ligands and Cu(II) complexes were carried out to ascertain their effectiveness in the inhibition of Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4), a highly virulent pathogen against Cavendish banana in tropical region. A few of the complexes showed noteworthy inhibition on the growth of Foc TR4 with complex 6 was the most potent antifungal agent.