The effect of pre-operative pregabalin on postoperative pain and morphine consumption after open gynaecological surgery

• Main Author: Keong, Lim Wei
• Format: Thesis
• Language: English
• Published: 2016
• Subjects: RG Gynecology and obstetrics
• Online Access: http://eprints.usm.my/42030/1/Dr._Lim_Wei_Keong-24_pages.pdf; http://eprints.usm.my/42030/
• Institution: Universiti Sains Malaysia

Introduction : Preoperative pregabalin has been shown to reduce postoperative pain scores and morphine consumption in certain surgical groups. We studied the effect of preoperative pregabalin on post operative pain relief among patients undergoing open gynaecological operation. Objective: This was a prospective, randomised, double blinded study on the efficacy of preoperative oral pregabalin 150mg in reducing postoperative morphine consumption and pain scores after undergoing open gynaecological operation.. Methodology : 60 patients undergoing open gynaecological operation that fulfilled inclusion and exclusion criteria were recruited in Hospital Universiti Sains Malaysia and randomized into two groups. Oral pregabalin 150mg was given to the pregabalin group (n=30) one hour prior to operation while placebo was given to the control group (n=30). A standardized regime of general anaesthesia was given to both groups and intravenous morphine was delivered via a patient controlled analgesia machine. Post operative pain scores at rest and movement were recorded using numeric rating scale at 0, 1, 4 and 24hours postoperatively. Total morphine usage was also recorded at those intervals. Results: There were no significant differences in resting pain scores (p= 0.083), moving pain score (p= 0.680) or morphine consumption (p= 0.740) at 24 hours postoperatively between pregabalin and control group. Conclusion : The use of 150mg oral pregabalin preoperatively given one hour prior to operation did not decrease post-operative pain score and morphine consumption for patients who underwent open gynaecological operation under general anaesthesia.