Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundi...
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2012
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my.usm.eprints.42246 http://eprints.usm.my/42246/ Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan Ma'amor, Nur Hasnah R5-920 Medicine (General) The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundice. However data on the Malaysian Malay population are scanty at best. The objectives of this study included: to determine the frequency of variants in the exons of the UGT1A1 gene in a population of term Malay neonates with jaundice and without jaundice, and to correlate the genotype finding with some phenotypic data. 2012-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42246/1/NUR_HASNAH_MA%27AMOR.pdf Ma'amor, Nur Hasnah (2012) Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan. Masters thesis, Universiti Sains Malaysia. |
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R5-920 Medicine (General) Ma'amor, Nur Hasnah Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| description |
The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundice. However data on the Malaysian Malay population are scanty at best. The objectives of this study included: to determine the frequency of variants in the exons of the UGT1A1 gene in a population of term Malay neonates with jaundice and without jaundice, and to correlate the genotype finding with some phenotypic data. |
| format |
Thesis |
| author |
Ma'amor, Nur Hasnah |
| author_facet |
Ma'amor, Nur Hasnah |
| author_sort |
Ma'amor, Nur Hasnah |
| title |
Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| title_short |
Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| title_full |
Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| title_fullStr |
Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| title_full_unstemmed |
Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan |
| title_sort |
screening of ugt1a1 gene and genotype-phenotype correlationship in neonatal jaundice from a sample of newborns in kelantan |
| publishDate |
2012 |
| url |
http://eprints.usm.my/42246/1/NUR_HASNAH_MA%27AMOR.pdf http://eprints.usm.my/42246/ |
| _version_ |
1643710451561791488 |