Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis

Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis

The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity...

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Main Author: Parumasivam, Thaigarajan
Format: Thesis
Language:English
Published: 2012
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf
http://eprints.usm.my/42806/
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Institution: Universiti Sains Malaysia
Language: English
id my.usm.eprints.42806
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spelling my.usm.eprints.42806 http://eprints.usm.my/42806/ Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis Parumasivam, Thaigarajan RS1-441 Pharmacy and materia medica The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH. 2012-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf Parumasivam, Thaigarajan (2012) Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Parumasivam, Thaigarajan
Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
description The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH.
format Thesis
author Parumasivam, Thaigarajan
author_facet Parumasivam, Thaigarajan
author_sort Parumasivam, Thaigarajan
title Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
title_short Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
title_full Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
title_fullStr Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
title_full_unstemmed Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
title_sort studies on the activity of isoniazid derivatives and their combinations with other anti-tb drugs on mycobacterium tuberculosis
publishDate 2012
url http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf
http://eprints.usm.my/42806/
_version_ 1643710582440853504

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