The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives

The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives

Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(...

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Main Author: Al-Mudaris, Zena A. Abdul Hameed
Format: Thesis
Language:English
Published: 2011
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf
http://eprints.usm.my/42887/
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Institution: Universiti Sains Malaysia
Language: English
id my.usm.eprints.42887
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spelling my.usm.eprints.42887 http://eprints.usm.my/42887/ The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives Al-Mudaris, Zena A. Abdul Hameed RS1-441 Pharmacy and materia medica Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf Al-Mudaris, Zena A. Abdul Hameed (2011) The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Al-Mudaris, Zena A. Abdul Hameed
The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
description Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity.
format Thesis
author Al-Mudaris, Zena A. Abdul Hameed
author_facet Al-Mudaris, Zena A. Abdul Hameed
author_sort Al-Mudaris, Zena A. Abdul Hameed
title The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_short The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_full The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_fullStr The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_full_unstemmed The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_sort study of anticancer properties of benzyl-o-vanillin and its derivatives
publishDate 2011
url http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf
http://eprints.usm.my/42887/
_version_ 1643710603369381888

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