Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma

Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essent...

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Main Author: Khare, Vani
Format: Thesis
Language:English
Published: 2013
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Online Access:http://eprints.usm.my/43997/1/Vani%20Khare.pdf
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Institution: Universiti Sains Malaysia
Language: English
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spelling my.usm.eprints.43997 http://eprints.usm.my/43997/ Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma Khare, Vani QH1 Natural history (General - Including nature conservation, geographical distribution) Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature. 2013-02 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43997/1/Vani%20Khare.pdf Khare, Vani (2013) Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic QH1 Natural history (General - Including nature conservation, geographical distribution)
spellingShingle QH1 Natural history (General - Including nature conservation, geographical distribution)
Khare, Vani
Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
description Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature.
format Thesis
author Khare, Vani
author_facet Khare, Vani
author_sort Khare, Vani
title Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_short Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_full Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_fullStr Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_full_unstemmed Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_sort role of cyclooxygenases in zebrafish oogenesis and their transcriptional regulation by peroxisome proliferator activated receptor gamma
publishDate 2013
url http://eprints.usm.my/43997/1/Vani%20Khare.pdf
http://eprints.usm.my/43997/
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