Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats

Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats

Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main ps...

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Main Author: Yusoff, Nurul Hasnida Mohammad
Format: Thesis
Language:English
Published: 2018
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf
http://eprints.usm.my/44127/
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Institution: Universiti Sains Malaysia
Language: English
id my.usm.eprints.44127
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spelling my.usm.eprints.44127 http://eprints.usm.my/44127/ Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats Yusoff, Nurul Hasnida Mohammad RS1-441 Pharmacy and materia medica Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm. 2018-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf Yusoff, Nurul Hasnida Mohammad (2018) Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Yusoff, Nurul Hasnida Mohammad
Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
description Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm.
format Thesis
author Yusoff, Nurul Hasnida Mohammad
author_facet Yusoff, Nurul Hasnida Mohammad
author_sort Yusoff, Nurul Hasnida Mohammad
title Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
title_short Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
title_full Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
title_fullStr Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
title_full_unstemmed Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
title_sort mitragynine-induced conditioned place preference (cpp) and the profiles of dopamine and its metabolites in rats
publishDate 2018
url http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf
http://eprints.usm.my/44127/
_version_ 1643710923656921088

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