Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax

• Main Authors: Ismail, Norzila, Ibrahim, Wan Suriyani Wan, Salleh, Siti Farhanah Mohd, Yajid, Aidy Irman, Wong, Michael Pak-Kai, Hashim, Mohd Nizam Md
• Format: Article
• Language: English
• Published: Elsevier 2019
• Subjects: RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.usm.my/44687/1/AsianPacJTropBiomed_2019_9_6_249_260397-OCR%20-2.pdf; http://eprints.usm.my/44687/; http://www.apjtb.org/text.asp?2019/9/6/249/260397
• Institution: Universiti Sains Malaysia

Objective: To determine the anti-proliferative activity of Abrus precatorius (A. precatorius) leaf extracts and their effect on cell death. Methods: A. precatorius leaves were extracted successively with hexane, ethyl acetate and methanol by Soxhlet extraction. Aqueous extract was prepared by dec...