Clozapine-Induced Myocarditis and Pericarditis
Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine wa...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan International Cultural Exchange Foundation
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf http://eprints.usm.my/44712/ http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A
50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood
pressure and fever after 17 days of starting clozapine was studied.
Result: Elevated creatinine kinase at 532 U/l along with WBC and neutrophil count at 21.40 and 16.83 x 1071 respectively
indicated an acute myocarditis. Additionally, pericardium involvement was suggested by V1-V4 ST elevation and absence of T
wave inversion.
Conclusion: The emergence of tachycardia, low blood pressure and fever in patient who is recently started on clozapine
treatment should be investigated for cardiac complications. Old age and concomitant treatment with sodium valproate possibly
increased the risk of clozapine-induced cardiac side-effects |
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